• NAD+ supplement NR 300mg capsule
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SanareLab

NAD+ with NR 300 mg | Cellular Energy & Metabolism Supplement

NAD+ with NR 300 mg | Cellular Energy & Metabolism Supplement

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$29.99 USD
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Each capsule delivers 300 mg of Nicotinamide Riboside Chloride — a direct precursor to NAD+ (nicotinamide adenine dinucleotide), the coenzyme essential for cellular energy production, DNA repair, and metabolic function. Available in 30, 60, and 90 capsule bottles. Vegan, non-GMO, gluten-free. GMP-certified U.S. facility.

300 mg

NR per capsule

+3.1x

NAD+ increase in blood

30 / 60 / 90

Capsules per bottle

USA

GMP-certified facility

NAD+ Nicotinamide Riboside — Daily Cellular Renewal by Sanare Lab

Clinical Data

Blood NAD+

+3.1x

NAD+ levels increased 3.1-fold after 5 weeks of NR supplementation and remained elevated at 20 weeks (RCT, 58 subjects, 2025)

Brain NAD+

+16%

Cerebral NAD+ increased by 16% within 4 hours after a single dose of NR (7T MRI study, 10 healthy volunteers)

Blood Pressure

-8 mmHg

Systolic BP decreased by 8 mmHg vs. placebo after 6 weeks in adults with elevated baseline SBP (Phase IIa trial)

Inflammation

-46%

IL-8 (inflammatory marker) reduced by 46% after 6 weeks of NR vs. placebo (RCT, 40 subjects, Nature 2024)

Whole Blood NAD+

+71 µM

Whole blood NAD+ rose by 71.1 µM after 6 weeks of supplementation in older adults (Nature Aging 2024)

Cytokines

IL-6, TNF-a ↓

21-day NR supplementation decreased circulating IL-6, IL-5, IL-2, and TNF-a in older adults

Nicotinamide Riboside — Everyday Cellular Energy Support

Why NAD+ Matters

NAD+ is required by every cell in your body. It fuels mitochondrial energy production (ATP), activates sirtuins (SIRT1, SIRT3) that regulate DNA repair and gene expression, and maintains metabolic homeostasis. NAD+ levels decline 50% between ages 40 and 60. NR is the most efficient oral precursor — it converts to NAD+ via the NR kinase pathway, bypassing rate-limiting steps that bottleneck other precursors.

Mechanism of Action

Nicotinamide Riboside (NR) is converted to NMN by NR kinases (NRK1/NRK2), then to NAD+ by NMNAT enzymes. Unlike nicotinamide or nicotinic acid, NR enters the salvage pathway without inhibiting sirtuins and causes no flushing. Oral NR shows superior bioavailability — a single 1,000 mg dose elevates whole-blood NAD+ up to 2.7-fold within hours.

Elevated NAD+ activates SIRT1 (nuclear deacetylase regulating gene expression and DNA repair), SIRT3 (mitochondrial deacetylase boosting oxidative phosphorylation), and PARP-1 (DNA damage repair enzyme). NR also increases NAAD by 45-fold — a biomarker confirming effective NAD+ pathway activation in tissues including heart, liver, and skeletal muscle.

Nicotinamide Riboside — Performance, Everyday

What's Inside

  • 300 mg Nicotinamide Riboside Chloride per capsule
  • Vegetable cellulose capsule (vegan)
  • Rice flour, magnesium stearate
  • Non-GMO & gluten-free
  • No artificial preservatives or fillers
  • 1 capsule daily with or without food
Nicotinamide Riboside 300mg — Everyday Cellular Energy Support

Key Areas of Support

✅

Cellular Energy & ATP Production

NAD+ is a required cofactor in mitochondrial Complex I. Higher NAD+ = more efficient oxidative phosphorylation and ATP output

✅

DNA Repair & Genomic Integrity

NAD+ fuels PARP-1 and sirtuins — the enzymes responsible for detecting and repairing DNA strand breaks

✅

Cardiovascular Support

Clinical trial: -8 mmHg systolic BP and reduced arterial stiffness (CFPWV) after 6 weeks of NR supplementation

✅

Anti-Inflammatory Action

NR reduced IL-8 by 46%, decreased IL-6, IL-2, IL-5, TNF-a in older adults across multiple clinical trials

✅

Healthy Aging & Sirtuin Activation

NR activates SIRT1 and SIRT3, mimicking caloric restriction pathways. Exploratory data shows reduced epigenetic aging markers

Nicotinamide Riboside 300mg — Cellular Energy, Daily

Supplement Facts

Nicotinamide Riboside 300mg Supplement Facts

Storage

Store at room temperature (68-77°F / 20-25°C). Keep sealed in original container, away from moisture and direct sunlight. Shelf life: approximately 2 years from manufacture date.

Frequently Asked Questions

What is Nicotinamide Riboside and how does it boost NAD+?

NR is a form of vitamin B3 and a direct precursor to NAD+. It converts to NAD+ via NR kinase enzymes (NRK1/NRK2), bypassing rate-limiting steps in the de novo pathway. Clinical trials show NR raises blood NAD+ 2.7x-3.1x within days to weeks of supplementation, with no flushing side effects.

How should I take it?

Take 1 capsule daily with or without food. NAD+ levels begin rising within hours of the first dose and reach sustained elevation within 5 weeks. Consistent daily use is recommended for cumulative benefits.

How is NR different from NMN or Niacin?

NR converts to NMN first, then to NAD+. Unlike niacin (nicotinic acid), NR causes no flushing. Unlike nicotinamide, NR does not inhibit sirtuins at supplemental doses. Oral NR shows superior hepatic bioavailability compared to NAM and NA in comparative studies.

Is it safe?

Yes. NR has been evaluated in multiple RCTs at doses up to 2,000 mg/day with no serious adverse events. It is well-tolerated in both healthy adults and clinical populations including older adults with COPD. Made in a GMP-certified U.S. facility, vegan, non-GMO, gluten-free.

Can I combine it with other supplements?

NR pairs well with resveratrol, CoQ10, and other longevity compounds. For comprehensive wellness, consider pairing with Hyaluronic Acid for joint and skin support or Curcumin Turmeric for anti-inflammatory synergy.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before starting any supplement regimen. Contact support@sanarelab.com for questions.

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