SanareLab
NAD+ Nicotinamide Riboside 300mg | Cellular Energy & Anti-Aging | Sanare Lab
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Each capsule delivers 300 mg of Nicotinamide Riboside Chloride — a direct precursor to NAD+ (nicotinamide adenine dinucleotide), the coenzyme essential for cellular energy production, DNA repair, and metabolic function. Available in 30, 60, and 90 capsule bottles. Vegan, non-GMO, gluten-free. GMP-certified U.S. facility.
300 mg
NR per capsule
+3.1x
NAD+ increase in blood
30 / 60 / 90
Capsules per bottle
USA
GMP-certified facility
Clinical Data
Blood NAD+
+3.1x
NAD+ levels increased 3.1-fold after 5 weeks of NR supplementation and remained elevated at 20 weeks (RCT, 58 subjects, 2025)
Brain NAD+
+16%
Cerebral NAD+ increased by 16% within 4 hours after a single dose of NR (7T MRI study, 10 healthy volunteers)
Blood Pressure
-8 mmHg
Systolic BP decreased by 8 mmHg vs. placebo after 6 weeks in adults with elevated baseline SBP (Phase IIa trial)
Inflammation
-46%
IL-8 (inflammatory marker) reduced by 46% after 6 weeks of NR vs. placebo (RCT, 40 subjects, Nature 2024)
Whole Blood NAD+
+71 µM
Whole blood NAD+ rose by 71.1 µM after 6 weeks of supplementation in older adults (Nature Aging 2024)
Cytokines
IL-6, TNF-a ↓
21-day NR supplementation decreased circulating IL-6, IL-5, IL-2, and TNF-a in older adults
Why NAD+ Matters
NAD+ is required by every cell in your body. It fuels mitochondrial energy production (ATP), activates sirtuins (SIRT1, SIRT3) that regulate DNA repair and gene expression, and maintains metabolic homeostasis. NAD+ levels decline 50% between ages 40 and 60. NR is the most efficient oral precursor — it converts to NAD+ via the NR kinase pathway, bypassing rate-limiting steps that bottleneck other precursors.
Mechanism of Action
Nicotinamide Riboside (NR) is converted to NMN by NR kinases (NRK1/NRK2), then to NAD+ by NMNAT enzymes. Unlike nicotinamide or nicotinic acid, NR enters the salvage pathway without inhibiting sirtuins and causes no flushing. Oral NR shows superior bioavailability — a single 1,000 mg dose elevates whole-blood NAD+ up to 2.7-fold within hours.
Elevated NAD+ activates SIRT1 (nuclear deacetylase regulating gene expression and DNA repair), SIRT3 (mitochondrial deacetylase boosting oxidative phosphorylation), and PARP-1 (DNA damage repair enzyme). NR also increases NAAD by 45-fold — a biomarker confirming effective NAD+ pathway activation in tissues including heart, liver, and skeletal muscle.
What's Inside
- 300 mg Nicotinamide Riboside Chloride per capsule
- Vegetable cellulose capsule (vegan)
- Rice flour, magnesium stearate
- Non-GMO & gluten-free
- No artificial preservatives or fillers
- 1 capsule daily with or without food
Key Areas of Support
Supplement Facts
Storage
Store at room temperature (68-77°F / 20-25°C). Keep sealed in original container, away from moisture and direct sunlight. Shelf life: approximately 2 years from manufacture date.
Frequently Asked Questions
What is Nicotinamide Riboside and how does it boost NAD+?
NR is a form of vitamin B3 and a direct precursor to NAD+. It converts to NAD+ via NR kinase enzymes (NRK1/NRK2), bypassing rate-limiting steps in the de novo pathway. Clinical trials show NR raises blood NAD+ 2.7x-3.1x within days to weeks of supplementation, with no flushing side effects.
How should I take it?
Take 1 capsule daily with or without food. NAD+ levels begin rising within hours of the first dose and reach sustained elevation within 5 weeks. Consistent daily use is recommended for cumulative benefits.
How is NR different from NMN or Niacin?
NR converts to NMN first, then to NAD+. Unlike niacin (nicotinic acid), NR causes no flushing. Unlike nicotinamide, NR does not inhibit sirtuins at supplemental doses. Oral NR shows superior hepatic bioavailability compared to NAM and NA in comparative studies.
Is it safe?
Yes. NR has been evaluated in multiple RCTs at doses up to 2,000 mg/day with no serious adverse events. It is well-tolerated in both healthy adults and clinical populations including older adults with COPD. Made in a GMP-certified U.S. facility, vegan, non-GMO, gluten-free.
Can I combine it with other supplements?
NR pairs well with resveratrol, CoQ10, and other longevity compounds. For comprehensive wellness, consider pairing with Hyaluronic Acid for joint and skin support or Curcumin Turmeric for anti-inflammatory synergy.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before starting any supplement regimen. Contact support@sanarelab.com for questions.
Looking to boost your cellular energy and support healthy aging? Sanare Lab's NAD+ with Nicotinamide Riboside delivers 300mg of NR per capsule to replenish your body's declining NAD+ levels. NAD+ is essential for energy production, DNA repair, and cellular health — but levels naturally drop with age. This research-backed supplement helps restore optimal NAD+ levels for improved vitality.
Key Benefits
- ✓ 300mg Nicotinamide Riboside – Clinically relevant dose to effectively boost NAD+ levels
- ✓ Cellular Energy Support – Enhances mitochondrial function for improved energy production
- ✓ Healthy Aging – Supports DNA repair mechanisms and cellular maintenance processes
- ✓ Cognitive Clarity – NAD+ is essential for optimal brain cell function and mental sharpness
- ✓ Research-Backed & Tested – Based on published clinical studies, every batch third-party verified
Frequently Asked Questions
What is NAD+ and why is it important?
NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme present in every cell of your body that is essential for energy production, DNA repair, and cellular communication. NAD+ levels naturally decline with age — by age 50, levels can drop to half of what they were at age 20. Supplementing with NAD+ precursors like Nicotinamide Riboside helps restore these critical levels.
What is Nicotinamide Riboside (NR)?
Nicotinamide Riboside (NR) is a form of Vitamin B3 that serves as one of the most efficient precursors to NAD+. Unlike other NAD+ precursors, NR is efficiently absorbed and converted to NAD+ through a unique metabolic pathway. Research from leading institutions has shown NR supplementation can significantly increase NAD+ levels in the body.
What are the benefits of NAD+ supplementation?
Boosting NAD+ levels through NR supplementation supports cellular energy production and metabolism, healthy aging at the cellular level, DNA repair mechanisms, mitochondrial function and efficiency, cognitive function and mental clarity, and cardiovascular health. Research continues to reveal new benefits of maintaining optimal NAD+ levels.
How much NAD+ NR should I take daily?
Each Sanare Lab capsule contains 300mg of Nicotinamide Riboside. The standard recommended serving is one capsule daily, taken with or without food. For specific dosage guidance based on your individual health goals, consult with your healthcare provider.
Is NAD+ NR safe for long-term use?
Nicotinamide Riboside has been extensively studied in human clinical trials and has demonstrated an excellent safety profile at recommended dosages. Sanare Lab's NAD+ NR formula is third-party tested for purity and manufactured in a GMP-certified facility in the USA.
Customer Reviews
Great NAD supplement.
I've tried several NAD+ supplements and this one is by far the best. Clean ingredients, no fillers. I take it every morning and feel more alert and energized. Great value for the quality you get.
Started taking this to support healthy aging and cognitive function. After 3 weeks, I noticed better mental clarity and focus throughout the day. Quality product, fast shipping. Will definitely reorder.
I've been taking this NAD+ supplement for about a month now and I can definitely feel a difference in my energy levels. No more afternoon crashes. The capsules are easy to swallow and I haven't experienced any side effects. Highly recommend!
My blood pressure started going up on second day and at the end of the week I started feeling pain in my kidneys.
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